Enantioselectivity in the Noyori–Ikariya Asymmetric Transfer Hydrogenation of Ketones
نویسندگان
چکیده
Asymmetric transfer hydrogenation (ATH) is an important catalytic process in the fragrance and pharmaceutical industries. The Noyori–Ikariya chiral molecular ruthenium complex has been catalyst...
منابع مشابه
Asymmetric Hydrogenation and Transfer Hydrogenation of Ketones
Optically active alcohols are important building blocks in the synthesis of fine chemicals, pharmaceuticals, agrochemicals, flavors and fragrances as well as functional materials (Arai & Ohkuma, 2011; Klingler, 2007). Furthermore, molecular hydrogen is without doubt the cleanest reducing agent, with complete atom efficiency. Therefore, the catalytic, asymmetric hydrogenation (AH) of prochiral k...
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Ru complexes with chiral diphosphines and amine-based ligands achieve high catalytic activity and enantioselectivity for the hydrogenation of ketones under neutral to slightly basic conditions. The chiral environment is controllable by changing the combination of these two ligands. A concerted six-membered transition state is proposed to be the origin of the high reactivity. The eta(6)-arene/Ts...
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The preparation of a range of asymmetric iron and ruthenium-cyclone complexes, and their application to the asymmetric reduction of a ketone, are described. The enantioselectivity of ketone reduction is influenced by a single chiral centre in the catalyst, as well as by the planar chirality in the catalyst. This represents the first example of asymmetric ketone reduction using an iron cyclone c...
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ژورنال
عنوان ژورنال: Organometallics
سال: 2021
ISSN: ['1520-6041', '0276-7333']
DOI: https://doi.org/10.1021/acs.organomet.1c00201